I am lucky because I get to work with the smartest, most creative, and most devoted group of students and postdoctoral fellows imaginable.
I remember the day we found the gene for the inter-species signaling molecule like it was yesterday. We got the gene, and we plugged it into a database. And we immediately saw that this gene was in an amazing number of species of bacteria. It was a huge moment of realization.
It's a manic-depressive life. You run in here, you open your incubator, your experiment makes no sense, you think, 'I hate this job.' Then ten minutes later you think, 'Well, now, maybe I'll try this or I'll try that.' You do it because you know there will be an 'a-ha!' day.
When antibiotics first came out, nobody could have imagined we'd have the resistance problem we face today. We didn't give bacteria credit for being able to change and adapt so fast.
Everybody, as soon as they do a good experiment, their first thought in this lab is, 'That can't be right. I must have screwed it up. What did I do wrong?' And that's the best kind of scientist because they're filled with this self-doubt. And if I'm going to be honest, that's who I am. And it's what drives me.
Bacteria are single-celled organisms. Bacteria are the model organisms for everything that we know in higher organisms. There are 10 times more bacterial cells in you or on you than human cells.
Bacteria live in unbelievable mixtures of hundreds or thousands of species. Like on your teeth. There are 600 species of bacteria on your teeth every morning.
Think about all kinds of infectious diseases, like mumps or measles or chicken pox. When a virgin population encountered those pathogens, it ravaged the population, and now they're childhood diseases, and eventually they won't even be that. That's our relationship with bacteria, going through time.
I went to UC Davis because I wanted to be a vet. It's a great profession if it's right for you, but it's memorizing the bones and the muscles, and I am terrible at stuff like that. Also, there's a lot of blood and gore involved.
If a bacterium is trying to infect you, it won't secrete alone, because your immune system will block it. Bacteria will hide until they can all act together and make an impact.
So, okay, I'm not a genius. Vincent Van Gogh and Albert Einstein were geniuses.
I called up and said, 'Dad, I won a MacArthur.' My father goes: 'I always thought your sister would win that,' and I said, 'Dad, just say congratulations and keep your private thoughts private.' At that point he laughed, then burst into tears, and it was obvious that he was so happy and proud.
My bacteria glow in the dark - no human being doesn't like that.
My job is to teach someone something they never knew, but it should not be like you're in a prisoner-of-war camp. I'm supposed to be teaching you but also entertaining you. You're giving me an hour of your time. It should be lively. We're on a hunt, it's a mystery, and it's amazing.
If I didn't teach the aerobics class, I wouldn't come, and I need to stay in shape. I've got a whole wardrobe of sleeveless dresses and strapless gowns, not to mention the short skirts.
We're scientists; we're curious about how nature works, but we're also do-gooders. It's fantastic to think that the same experiments we'd do to understand how information gets into cells could have a practical side to them, too.
I was a huge athlete as a kid. I was on every sports team.
