Grey's Anatomy
Grey's Anatomy

Dr. Derek Shepherd: Do you happen to know what time of year neurosurgeons are the busiest, Dr. Stevens?
Dr. Isobel "Izzie" Stevens: There's a time of year?
Dr. Derek Shepherd: There's no hard or fast rule, but brain injuries tend to pile up around the holidays. Like our friend here. Folks fall off their roofs while they string up

lights. Or they go skating for the first time in a decade and break their heads open. And every year people drive through blizzards to get to parties where they kiss germ-infected strangers under poisonous mistletoe. And then they get so drunk that they smash their heads through their windshield on their way home. Like I said, there's no hard or fast rule.

Grey's Anatomy
Grey's Anatomy

Dr. Meredith Grey: Goodbye, Derek.
Dr. Derek Shepherd: Goodbye, Meredith.

Grey's Anatomy
Grey's Anatomy

Dr. Preston Burke: The only person that can keep a promise so big is God, and I haven't seen him pick up a scalpel lately.

Grey's Anatomy
Grey's Anatomy

Dr. Meredith Grey: I have custody of a penis?

Grey's Anatomy
Grey's Anatomy

Jane Burke: Do you know when to walk away? Do you know when not to take less than you deserve?

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: [to Alex] You gave me syph!

Grey's Anatomy
Grey's Anatomy

Dr. Meredith Grey: Maybe we're not supposed to be happy. Maybe gratitude has nothing to do with joy. Maybe being grateful means recognizing what you have for what it is. Appreciating small victories. Admiring the struggle it takes simply to be human. Maybe we're thankful for the familiar things we know. And maybe we're thankful for the things we'll never know. At the end of the

day, the fact that we have the courage to still be standing is reason enough to celebrate.

Grey's Anatomy
Grey's Anatomy

Dr. Alex Karev: Here's the thing - I like your rack.
Dr. Isobel "Izzie" Stevens: God, what is wrong with you? Why do you have to be so - what is wrong with you?
Dr. Alex Karev: I like your rack and I'd want them around if I could have them, trust me I would, but it wouldn't be the end of the world if you got rid of them... because

really, I'd want *you*.
[Izzie slaps him]
Dr. Alex Karev: Ow! What was that for?
[she kisses him]

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: Do you remember when he wallpapered the hospital with pictures of you in your underwear?
Dr. Isobel "Izzie" Stevens: Yeah. Yeah, I do.
Dr. Alex Karev: It was before I knew you.

Grey's Anatomy
Grey's Anatomy

Dr. Addison Shepherd: [Addison is annoyed that Derek has just caught a trout and has brought it inside] Why did you bring a trout into the trailer?

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: I don't think you understand. Me - gonads! You - ovaries!
Dr. Isobel "Izzie" Stevens: Oh, that reminds me. We are out of tampons.
Dr. George O'Malley: You're parading through the bathroom in your underwear, while I'm naked in the shower!
Dr. Isobel "Izzie" Stevens: Will you add it to your

list, please?
Dr. George O'Malley: What?
Dr. Isobel "Izzie" Stevens: Tampons!
Dr. Meredith Grey: To the list. It's your turn.
Dr. George O'Malley: I am a man! I don't buy girl products. I don't want to see you walking in while I'm in the shower. And I don't wanna see you in your underwear!

Dr. Isobel "Izzie" Stevens: It doesn't bother me, okay? Look at me in my underwear, George. Take your time, it's no big deal.

Grey's Anatomy
Grey's Anatomy

Dr. Alex Karev: Morning, Dr. Model.
Dr. Isobel "Izzie" Stevens: Dr. Evil Spawn.
Dr. Alex Karev: [he sees a tattoo on her lower stomach] Ooooh, nice tat. Do they airbrush that out for the catalogs?
Dr. Isobel "Izzie" Stevens: I don't know. What do they do for the 666 on your skull?

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: This shift is a marathon, not a sprint. Eat.
Dr. Isobel "Izzie" Stevens: I can't.
Dr. George O'Malley: You should eat something.
Dr. Isobel "Izzie" Stevens: You try eating after performing 17 rectal exams. The Nazi hates me.
Dr. George O'Malley: The Nazi's a

resident. I have attendings hating me.

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: [talking to himself] Oh, hi, chief. Nope, not much going on, well, other than your intern chief making out with my friend in the stairwell, but hey... sponge duty sucks.
Dr. Meredith Grey: [walks up beside him] Talking to yourself now?
Dr. George O'Malley: Yes. No.
[pause]
Dr. George

O'Malley: Damn it. I'm a bad sponge. A leaky sponge. I'm gonna leak all the wrong secrets. I'm a bad liar. I can't even lie about talking to myself.

Grey's Anatomy
Grey's Anatomy

Dr. Meredith Grey: I want facts and until I get them my pants are staying on.

Grey's Anatomy
Grey's Anatomy

Mr. Levangie: I know it's not perfect, but it's life. Life is messy sometimes.

Grey's Anatomy
Grey's Anatomy

Dr. Alex Karev: Why are you helping me?
Dr. Isobel "Izzie" Stevens: [yells] 'Cause it's what Jesus would freaking do!

Grey's Anatomy
Grey's Anatomy

Dr. Isobel "Izzie" Stevens: Mr. Humphrey? Mr. Humphrey, I'm sorry to wake you.
Mr. Humphrey: C'mon. What time is it?
Dr. Isobel "Izzie" Stevens: Ten after five. I'm sorry, I just need to do a brief exam. If you could just sit up for one moment.
[he sits up]
Dr. Isobel "Izzie" Stevens: Thanks. This might be a little bit

cold. So just take a deep breath.
[he looks at her funny]
Dr. Isobel "Izzie" Stevens: If you could just take a deep breath.
Mr. Humphrey: You're not a doctor!
Dr. Isobel "Izzie" Stevens: I'm Dr. Stevens, but you can call me Izzie. I'll be helping Dr. Bailey with your biopsy this morning.
Mr. Humphrey: No, I don't think so. No.


Dr. Isobel "Izzie" Stevens: Mr. Humphrey, this will just take a moment.
Mr. Humphrey: No, get me Dr. Bailey or Dr. Victor.
Dr. Isobel "Izzie" Stevens: I- I just need to do a brief...
Mr. Humphrey: You don't need to do anything. Is this you?
[he shows Izzie a picture in a magazine of herself posing in lingerie]
Mr.

Humphrey: Is this you? It is, isn't it? Get out of my room!
Dr. Isobel "Izzie" Stevens: Mr. Humphrey...
Mr. Humphrey: Get out of my room!

Grey's Anatomy
Grey's Anatomy

Dr. Isobel "Izzie" Stevens: [Sshe slams down the magazine] This is who I was. It has nothing to do with who I am now. I'm a physician. A surgeon! And I am just as qualified as any other intern on this floor. So you're just going to have to get over your chauvinist crap and allow me to do my job.
Mr. Humphrey: I'm sure you're a very good doctor.
Dr. Isobel

"Izzie" Stevens: Then what is your problem?
Mr. Humphrey: Look, I fantasized about you. About the woman in this photo, whoever she is. I'm not proud of it, but it's a fact. Do you know what they're gonna do to me today? I have cancer. And they're gonna lift up my legs and expose me to the world, and cut out my prostate, and my nerves. Effectively neuter me. So is it so hard to

understand that I don't want the woman who is in that photo to witness... my emasculation?

Grey's Anatomy
Grey's Anatomy

Dr. George O'Malley: Uh, Mr. Mackie I can't go out with you. You're not my type, I mean, you're a guy.
Lloyd Mackie: George, I knew you weren't gay.