Failure is enriching. It's also important to accept that you'll make mistakes - it's how you build your expertise. The trick is to learn a positive lesson from all of life's negative moments.
If you're playing a negative character, sooner or later it rubs off on you. Some people don't mind living in that state, but I don't want to be there anymore. I don't want to live in a state of depression.
Fear invariably and universally induces disengagement, and disengagement is negative division of labor.
No one working as an astronomer is shackled in chains. This is a tremendous profession. There are lots of neat people, and you get to do cool things. If I had to say something negative, it's that there's often a whole lot of travel that takes me away from my children. That can be a bummer a lot of times.
Our thoughts really do create our lives. They've done a lot of research showing if you're an optimistic, positive person you will be a healthier person than if you're a sad, depressed, negative person.
There are countless studies on the negative spillover of job pressures on family life, but few on how job satisfaction enhances the quality of family life.
Skeptical doesn't have to necessarily be a negative thing. I think if you allow yourself to second guess things and look at things from a distance you don't immediately run into things blindfolded, so that's a positive.