Cable: Dubstep's for pussies!
Wade Wilson: You're so dark. Are you sure you're not from the DC universe?
Wade Wilson: Sorry I'm late. There was a bunch of handicapable children stuck in a tree. I had to...
Vanessa: Uh-uh.
Wade Wilson: You're right. I was fighting a caped badass, but then we discovered that his mom is named Martha, too.
Wade Wilson: [to Vanessa] I hope we sharpened the cream cheese spreader.
[Wade throws the spreader into the gunman's head, killing him]
Wade Wilson: [turns on time-travel device] I'll be right back. We're definitely naming our kid Cher!
Weasel: And last but not least... Peter.
Deadpool: Any power you wanna tell us about?
Peter: I don't... I don't have one. Um, I just saw the ad.
Deadpool: No superpowers at all?
Peter: Uh, I have both type 1 and 2 diabetes.
Deadpool: Ow! Oh!
Weasel: That's all the diabetes.
Deadpool: Right. Yeah, you got them all. If you find a type 3, let us know. Yeah. You're in.
Cable: You remind me of my wife.
Wade Wilson: I'm sorry?
Cable: I said you remind me...
Wade Wilson: No, I'm sorry that you said that while making heavy eye contact and applying lip balm.
Deadpool: Only best buddies execute pedophiles together.
Cable: I'm retrieving something from my utility bag.
Weasel: It's a goddamn fanny pack and you know it, you sick son of a bitch! The difference is night and day.
[from trailer]
Cable: I was born into war, bred into it. People think they understand pain, but they have no concept of it. What's the most pain you've ever felt? Maybe the kind that leaves you more machine than man.
Deadpool: [halts trailer] Wait, no, STOP! What in the actual ass? Dale! Why, why are the visual effects not done? It's a metal arm!
It's not like we're trying to remove a mustache! Oh fuck it, I'll do it myself...
Firefist: Stay back or Justin Bieber dies!
Deadpool: [to Negasonic Teenage Warhead] Ha! Justin Bieber. He called you Justin Bieber.
Deadpool: Any powers you wanna tell us about? Any, uh...
Peter: No. I don't have one. Um, I just saw the ad. I thought it looked fun.
Deadpool: ...You're in.
Dopinder: [in the background, throws a box of supplies] FUCK!
Deadpool: Cable, you get back to your family and you tell them Wade says hi. And promise me, promise me one thing: that you'll start judging people not by the color of the skin but by the content of their character.
Cable: Jesus...