Well, originally we found resveratrol just in a test tube, looking for molecules that would turn on this enzyme, this protein that seems to defend against diseases in aging.
We're pretty sure there's plenty of organic material on Pluto. The atmosphere is largely methane, and in sunlight, methane builds organic molecules. We see reddish stuff on the surface that we think is organic material.
People don't even understand that every bit of our food was once alive. We take another creature, plant, animal, microorganism, tear it apart in our mouths. And incorporate those molecules into our own bodies. We are the Earth in the most profound way.
No matter how closely you examine the water, glucose, and electrolyte salts in the human brain, you can't find the point where these molecules became conscious.
There are receptors to these molecules in your immune system, in your gut and in your heart. So when you say, 'I have a gut feeling' or 'my heart is sad' or 'I am bursting with joy,' you're not speaking metaphorically. You're speaking literally.
My own training is in the field of neuroendocrinology and I really became very fascinated many years ago with the molecules of emotion, molecules that we call neuropeptides.
It does not seem, however, that organic chemists were much worried about barriers to rotation in organic molecules in general at that time because there was no technique available to demonstrate the phenomenon experimentally.
The question we ask is - if there is life on other planets, should we expect it to be based on the same molecules, i.e. be universal - or should we expect it to depend on the local conditions, i.e. on the planet's geochemistry. So to find out, we try experiments on biomolecules, starting with such geochemistry conditions.
When we think of what is necessary for the phenomenon that we call life, we think of compartmentalization, keeping the molecules which are important for life in a membrane, isolated from the rest of the environment, but yet, in an environment in which they actually could originate together.
To a synthetic chemist, the complex molecules of nature are as beautiful as any of her other creations. The perception of that beauty depends on the understanding of chemical structures and their transformations, and, as with a treasured work of art, deepens as the subject is studied, perhaps even to a level approaching romance.
