I feel in the depths of my soul that it is the highest, most sacred, and most irreversible part of my obligation to preserve the union of these states, although it may cost me my life.
It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain, repeated depressive episodes do.
We have made mistakes. In our haste to do all things for all people, we did not foresee the full consequences of our actions. And when the people raised their voices, we didn't hear. But our deafness was only a temporary condition, and not an irreversible condition.
I'm choosing not to accept the Trumpification of the GOP as an irreversible fact.
I believe we are on an irreversible trend toward more freedom and democracy - but that could change.
As far as I am concerned this referendum should settle the matter. I believe it will one way or another be decisive. Britain will not want to go through this again. On the other hand if we vote to leave, this really is irreversible.
What politicians want to create is irreversible change because when you leave office someone changes it back again.
Nothing in the world is irreversible, not even capitalism.
The death of Abdel Nasser on September 28, 1970, was an irreversible setback for Egypt.
Humans have changed ecosystems more rapidly and extensively than in any comparable period of time in human history, largely to meet rapidly growing demands for food, fresh water, timber, fiber and fuel. This has resulted in a substantial and largely irreversible loss in the diversity of life on Earth.
