Excellence is a continuous process and not an accident.
Reticulocytes are terminally differentiating red blood cells that do not contain lysosome. Therefore, it was postulated that the degradation of hemoglobin in these cells is mediated by a non-lysosomal machinery.
The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.
To develop drugs for people, we basically dismantle the system. In the lab, we look at things the size of a cell or two. We dismantle life into very small models.
I had a PET scan, and it was cleared. Not one cell of cancer after three rounds of chemo. But I still had seven more just for safety, which was stupid. I should have just worked on therapy.
An excellent job with a dubious undertaking, which is like saying it would be great if it wasn't awful.
Those who have learned to walk on the threshold of the unknown worlds, by means of what are commonly termed par excellence the exact sciences, may then, with the fair white wings of imagination, hope to soar further into the unexplored amidst which we live.
There are over 7,000 different types of proteins in typical eukaryotic cells; the total number depends on the cell class and function.
At the end of the 1970s, I was a young researcher at the Weizmann Institute with an ambitious plan to shed light on one of the major outstanding questions concerning living cells: the process of protein biosynthesis.
Henrietta Lacks' cells are immortal. They are known as the HeLa cell line, and they have become deeply involved in all sorts of medical and genetic research - sometimes in the most unexpected ways.
