The identification of the genes which determine biological phenomena and the study of the control they exert on these phenomena has proven to be the most successful approach to a detailed understanding of the mechanism of biological processes.
As biologists, we contemplate with admiration and awe the wondrous array of sophisticated cell interactions and recognitions evolved in the T cell immune system, which must be a model for other similarly complex biological systems of highly differentiated organisms.
My interest was directed, from my medical student days, to Immunology, and particularly to the mechanism of hypersensitivity. I had suffered from bronchial asthma as a child and had developed a deep curiosity in allergic phenomena.
Some of the most significant advances in molecular biology have relied upon the methodology of genetics. The same statement may be made concerning our understanding of immunological phenomena.
The immune system has evolved the capacity to react specifically with a very large number of foreign molecules with which it had no previous contact while avoiding reactivity for autologous molecules, naturally antigenic in other species or in other individuals of the same species.
My primary and secondary education was in French, which had a lasting influence on my life.
While in medical school, I was drafted into the U.S. Army with the other medical students as part of the wartime training program, and naturalized American citizen in 1943. I greatly enjoyed my medical studies, which at the Medical College of Virginia were very clinically oriented.
In 1970, Dean Robert Ebert offered me the Chair of Pathology at Harvard Medical School. I moved to Harvard because I missed the university environment and, more particularly, the stimulating interaction with the eager, enthusiastic, and unprejudiced young minds of the students and fellows.
